Data/hora: 09/06/2024 13:46:20

Provedor de dados: | 5
País: | France
Título: | Exopolysaccharides produced by marine bacteria and their applications as glycosaminoglycan-like molecules
Autores: | Delbarre-ladrat, Christine; Sinquin, Corinne; Lebellenger, Lou; Zykwinska, Agata; Colliec-jouault, Sylvia.
Data: | 2014-10-08
Ano: | 2014
Palavras-chave: | Marine-derivedpolysaccharide; Biodiversity; Biologicalactivity; Structure; Modification; GAG-mimetic; Biosynthesis.
Resumo: | Although polysaccharides are ubiquitous and the most abundant renewable bio-components, their studies, covered by the glycochemistry and glycobiology fields, remain a challenge due to their high molecular diversity and complexity. Polysaccharides are industrially used in food products; human therapeutics fall into a more recent research field and pharmaceutical industry is looking for more and more molecules with enhanced activities. Glycosaminoglycans (GAGs) found in animal tissues play a critical role in cellular physiological and pathological processes as they bind many cellular components. Therefore, they present a great potential for the design and preparation of therapeutic drugs. On the other hand, microorganisms producing exopolysaccharides (EPS) are renewable resources meeting well the actual industrial demand. In particular, the diversity of marine microorganisms is still largely unexplored offering great opportunities to discover high value products such as new molecules and biocatalysts. EPS-producing bacteria from the marine environment will be reviewed with a focus on marine-derived EPS from bacteria isolated from deep-sea hydrothermal vents. Information on chemical and structural features, putative pathways of biosynthesis, novel strategies for chemical and enzymatic modifications and potentialities in the biomedical field will be provided. An integrated approach should be used to increase the basic knowledge on these compounds and their applications; new clean environmentally friendly processes for the production of carbohydrate bioactive compounds should also be proposed for a sustainable industry.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00241/35250/33764.pdf

DOI:10.3389/fchem.2014.00085

https://archimer.ifremer.fr/doc/00241/35250/

Formato: | application/pdf
Fonte: | Frontiers In Chemistry (2296-2646), 2014-10-08 , Vol. 2 , P. 1-15

Fonte:

2014 Delbarre-Ladrat,Sinquin,Lebellenger,Zykwinska and Colliec-Jouault.This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited,in accordance with accepted academic practice.No use,distribution or reproduction is permitted which does not comply with these terms

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