Data/hora: 07/06/2024 05:46:44

Provedor de dados: 	5	
País: 	France	
Título: 	Marine Exopolysaccharide Complexed with Scandium Aimed as Theranostic Agents	
Autores: 	Mazza, Mattia; Alliot, Cyrille; Sinquin, Corinne; Colliec-jouault, Sylvia; Reiller, Pascal E.; Huclier-markai, Sandrine.	
Data: 	2021-02	
Ano: 	2021	
Palavras-chave: 	Exopolysaccharides; Scandium; Theranostic; Characterization; Complexation.	
Resumo: 	Background: Exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium, showed anti-metastatic properties. They may represent a new class of ligands to be combined with theranostic radionuclides, such as 47Sc/44Sc. The goal of this work was to investigate the feasibility of such coupling. (2) Methods: EPSs, as well as heparin used as a drug reference, were characterized in terms of molar mass and dispersity using Asymmetrical Flow Field-Flow Fractionation coupled to Multi-Angle Light Scattering (AF4-MALS). The intrinsic viscosity of EPSs at different ionic strengths were measured in order to establish the conformation. To determine the stability constants of Sc with EPS and heparin, a Free-ion selective radiotracer extraction (FISRE) method has been used. (3) Results: AF4-MALS showed that radical depolymerization produces monodisperse EPSs, suitable for therapeutic use. EPS conformation exhibited a lower hydrodynamic volume for the highest ionic strengths. The resulting random-coiled conformation could affect the complexation with metal for high concentration. The LogK of Sc-EPS complexes have been determined and showing that they are comparable to the Sc-Hep. (4) Conclusions: EPSs are very promising to be coupled with the theranostic pair of scandium for Nuclear Medicine.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	https://archimer.ifremer.fr/doc/00681/79332/81844.pdf

DOI:10.3390/molecules26041143

https://archimer.ifremer.fr/doc/00681/79332/	
Editor: 	MDPI AG	
Formato: 	application/pdf	
Fonte: 	Molecules (1420-3049) (MDPI AG), 2021-02 , Vol. 26 , N. 4 , P. 1143 (23p.)	
Fonte: 	info:eu-repo/semantics/openAccess

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