Data/hora: 10/06/2024 05:43:59

Provedor de dados: 	5	
País: 	France	
Título: 	Tumorhead distribution to cytoplasmic membrane of neural plate cells is positively regulated by Xenopus p21-activated kinase 1 (X-PAK1)	
Autores: 	Wu, Chuan-fen; Delsert, Claude; Faure, Sandrine; Traverso, Edwin E.; Kloc, Malgorzata; Kuang, Jian; Etkin, Laurence D.; Morin, Nathalie.	
Data: 	2007-08	
Ano: 	2007	
Palavras-chave: 	Actin cytoskeleton; Differentiation; Proliferation; Neural plate; P21 activated kinase; Tumorhead.	
Resumo: 	Tumorhead (TH) regulates neural plate cell proliferation during Xenopus early development, and gain or loss of function prevents neural differentiation. TH shuttles between the nuclear and cytoplasmic/cortical cell compartments in embryonic cells. In this study, we show that subcellular distribution of TH is important for its functions. Targeting TH to the cell cortex/membrane potentiates a TH gain of function phenotype and results in neural plate expansion and inhibition of neuronal differentiation. We have found that TH subcellular localization is regulated, and that its shuttling between the nucleus and the cell cortex/cytoplasm is controlled by the catalytic activity of p21-activated kinase, X-PAK1. The phenotypes of embryos that lack, or have excess, X-PAK1 activity mimic the phenotypes induced by loss or gain of TH functions, respectively. We provide evidence that X-PAK1 is an upstream regulator of TH and discuss potential functions of TH at the cell cortex/cytoplasmic membrane and in the nucleus.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	http://archimer.ifremer.fr/doc/2007/publication-2996.pdf

DOI:10.1016/j.ydbio.2007.05.015	
Editor: 	Elsevier	
Relação: 	http://archimer.ifremer.fr/doc/00000/2996/	
Formato: 	application/pdf	
Fonte: 	Developmental Biology (0012-1606) (Elsevier), 2007-08 , Vol. 308 , N. 1 , P. 169-186	
Fonte: 	2007 Elsevier B.V. All rights reserved