Data/hora: 09/06/2024 05:23:05

Provedor de dados: | 5
País: | France
Título: | Assembly of HE800 exopolysaccharide produced by a deep-sea hydrothermal bacterium into microgels for protein delivery applications
Autores: | Zykwinska, Agata; Marquis, Melanie; Sinquin, Corinne; Cuenot, Stephane; Colliec-jouault, Sylvia.
Data: | 2016-05
Ano: | 2016
Palavras-chave: | Marine exopolysaccharide; Microgel particles; Microfibers; Microfluidic; Microencapsulation; Protein release.
Resumo: | Assembly of biopolymers into microgels is an elegant strategy for bioencapsulation with various potential biomedical applications. Such biocompatible and biodegradable microassemblies are developed not only to protect the encapsulated molecule but also to ensure its sustained local delivery. The present study describes the fabrication of microassemblies from a marine HE800 exopolysaccharide (EPS), which displays a glycosaminoglycan (GAG)-like structure and biological properties. HE800 EPS was assembled, through physical cross-linking with divalent ions, into microgel particles and microfibers using microfluidics. The microparticle morphology was highly affected by the polysaccharide concentration and its molecular weight. A model protein, namely Bovine Serum Albumin (BSA) was subsequently encapsulated within HE800 microparticles in one-step process using microfluidics. The protein release was tuned by the microparticle morphology with a lower protein amount released from the most homogeneous structures. Our findings demonstrate the high potential of HE800 EPS based microassemblies as innovative protein microcarriers for further biomedical applications.
Tipo: | Text
Idioma: | Inglês

Identificador:

https://archimer.ifremer.fr/doc/00311/42175/41475.pdf

DOI:10.1016/j.carbpol.2016.01.056

https://archimer.ifremer.fr/doc/00311/42175/

Editor: | Elsevier Sci Ltd
Formato: | application/pdf
Fonte: | Carbohydrate Polymers (0144-8617) (Elsevier Sci Ltd), 2016-05 , Vol. 142 , P. 213-221

Fonte:

2016 Elsevier Ltd. All rights reserved

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