Data/hora: 06/06/2024 11:55:32

Provedor de dados: 	5	
País: 	France	
Título: 	Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites	
Autores: 	Augusto, Ronaldo De Carvalho; Tetreau, Guillaume; Chan, Philippe; Walet-balieu, Marie-laure; Mello-silva, Clelia Christina; Santos, Claudia Portes; Grunau, Christoph.	
Data: 	2017-07	
Ano: 	2017	
Resumo: 	Background Schistosomiasis has been reported in 78 endemic countries and affects 240 million people worldwide. The digenetic parasite Schistosoma mansoni needs fresh water to compete its life cycle. There, it is susceptible to soluble compounds that can affect directly and/or indirectly the parasite's biology. The cercariae stage is one of the key points in which the parasite is vulnerable to different soluble compounds that can significantly alter the parasite's life cycle. Molluscicides are recommended by the World Health Organization for the control of schistosomiasis transmission and Euphorbia milii latex is effective against snails intermediate hosts. Methodology/Principal findings We used parasitological tools and electron microscopy to verify the effects of cercariae exposure to natural molluscicide (Euphorbia milii latex) on morphology, physiology and fitness of adult parasite worms. In order to generate insights into key metabolic pathways that lead to the observed phenotypes we used comparative transcriptomics and proteomics. Conclusions/Significance We describe here that the effect of latex on the adult is not due to direct toxicity but it triggers an early change in developmental trajectory and perturbs cell memory, mobility, energy metabolism and other key pathways. We conclude that latex has not only an effect on the vector but applies also long lasting schistosomastatic action. We believe that these results are of interest not only to parasitologists since it shows that natural compounds, presumably without side effects, can have an impact that occurred unexpectedly on developmental processes. Such collateral damage is in this case positive, since it impacts the true target of the treatment campaign. This type of treatment could also provide a rational for the control of other pests. Our results will contribute to enforce the use of E. milii latex in Brazil and other endemic countries as cheap alternative or complement to mass drug treatment with Praziquantel, the only available drug to cure the patients (without preventing reinfection).	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	https://archimer.ifremer.fr/doc/00398/50960/71803.tif

https://archimer.ifremer.fr/doc/00398/50960/71804.xls

https://archimer.ifremer.fr/doc/00398/50960/71805.xls

https://archimer.ifremer.fr/doc/00398/50960/71806.xls

https://archimer.ifremer.fr/doc/00398/50960/71807.xls

https://archimer.ifremer.fr/doc/00398/50960/71808.xlsx

https://archimer.ifremer.fr/doc/00398/50960/71809.gff

https://archimer.ifremer.fr/doc/00398/50960/71810.gff

https://archimer.ifremer.fr/doc/00398/50960/71811.gff

https://archimer.ifremer.fr/doc/00398/50960/72002.pdf

DOI:10.1371/journal.pntd.0005789

https://archimer.ifremer.fr/doc/00398/50960/	
Editor: 	Public Library Science	
Formato: 	application/pdf	
Fonte: 	Plos Neglected Tropical Diseases (1935-2735) (Public Library Science), 2017-07 , Vol. 11 , N. 7 , P. e0005789. (19p.)	
Fonte: 	info:eu-repo/semantics/openAccess

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