Data/hora: 07/06/2024 02:40:04

Provedor de dados: 	5	
País: 	France	
Título: 	Response of the pearl oyster Pinctada margaritifera to cadmium and chromium: Identification of molecular biomarkers	
Autores: 	Gueguen, Yannick; Saulnier, Denis; Santini, Adrien; Magre, Kevin; Garen, Pierre; Bernagout, Solene; Nohl, Marine; Bouisset, Patrick; Helme, Herehia; Planes, Serge; Le Moullac, Gilles.	
Data: 	2017-05	
Ano: 	2017	
Palavras-chave: 	Pinctada margaritifera; French Polynesia; Cadmium; Chromium; Gene expression; Metallothionein.	
Resumo: 	This study was designed to identify in the pearl oyster Pinctada margaritifera, used as a bio-accumulator, molecular biomarkers for the presence of heavy metals in the lagoon environment. Pearl oysters were exposed to 2 concentrations (1 and 10 μg L− 1) of cadmium (Cd) and chromium (Cr) compared to a control. Twelve target genes encoding proteins potentially involved in the response to heavy metal contamination with antioxidant, detoxification or apoptosis activities were selected. P. margaritifera accumulated Cd but not Cr, and mortality was related to the amount of Cd accumulated in tissues. In response to Cd-Cr contamination, metallothionein (MT) was significantly up-regulated by Cd-Cr at both concentrations, while 7 others (SOD, CAT, GPX, GSTO, GSTM, CASP, MDR) were down-regulated. Based on the development of these molecular tools, we propose that the pearl oyster, P. margaritifera, could be used as a sentinel species for heavy metal contamination in the lagoons of tropical ecosystems.	
Tipo: 	Text	
Idioma: 	Inglês	
Identificador: 	http://archimer.ifremer.fr/doc/00376/48707/49146.pdf

DOI:10.1016/j.marpolbul.2017.03.012

http://archimer.ifremer.fr/doc/00376/48707/	
Editor: 	Pergamon-elsevier Science Ltd	
Formato: 	application/pdf	
Fonte: 	Marine Pollution Bulletin (0025-326X) (Pergamon-elsevier Science Ltd), 2017-05 , Vol. 118 , N. 1-2 , P. 420-426	
Fonte: 	2017 Elsevier Ltd. All rights reserved.

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