Data/hora: 03/06/2024 08:14:40

Provedor de dados: | 5
País: | France
Título: | Bovine Norovirus: Carbohydrate Ligand, Environmental Contamination, and Potential Cross-Species Transmission via Oysters
Autores: | Zakhour, Maha; Maalouf, Haifa; Di Bartolo, Ilaria; Haugarreau, Larissa; Le Guyader, Francoise; Ruvoen-clouet, Nathalie; Le Saux, Jean-claude; Ruggeri, Franco Maria; Pommepuy, Monique; Le Pendu, Jacques.
Data: | 2010-10
Ano: | 2010
Resumo: | Noroviruses (NoV) are major agents of acute gastroenteritis in humans and the primary pathogens of shellfish-related outbreaks. Previous studies showed that some human strains bind to oyster tissues through carbohydrate ligands that are similar to their human receptors. Thus, based on presentation of shared norovirus carbohydrate ligands, oysters could selectively concentrate animal strains with increased ability to overcome species barriers. In comparison with human GI and GII strains, bovine GIII NoV strains, although frequently detected in bovine feces and waters of two estuaries of Brittany, were seldom detected in oysters grown in these estuaries. Characterization of the carbohydrate ligand from a new GIII strain indicated recognition of the alpha-galactosidase (alpha-Gal) epitope not expressed by humans, similar to the GIII. 2 Newbury2 strain. This ligand was not detectable on oyster tissues, suggesting that oysters may not be able to accumulate substantial amounts of GIII strains due to the lack of shared carbohydrate ligand and that they should be unable to contribute to select GIII strains with an increased ability to recognize humans.
Tipo: | Text
Idioma: | Inglês

Identificador:

http://archimer.ifremer.fr/doc/00014/12534/9527.pdf

DOI:10.1128/AEM.00671-10

Editor: | Amer Soc Microbiology
Relação: | http://archimer.ifremer.fr/doc/00014/12534/
Formato: | application/pdf
Fonte: | Applied And Environmental Microbiology (0099-2240) (Amer Soc Microbiology), 2010-10 , Vol. 76 , N. 19 , P. 6404-6411
Fonte: | 2010, American Society for Microbiology. All Rights Reserved.