Data/hora: 06/06/2024 00:49:24

Provedor de dados: 	52	
País: 	Brazil	
Título: 	Fabrication and Characterization of Gliclazide Loaded Microcapsules	
Autores: 	Asad,Muhammad; Bashir,Sajid; Mahmood,Tariq; Nazir,Imran; Imran,Muhammad; Karim,Sabiha; ul Hassnain,Fakhar.	
Data: 	2014-12-01	
Ano: 	2014	
Palavras-chave: 	Microcapsules; Gliclazide; Ionotropic-gelation method; Guar gum; Pectin.	
Resumo: 	This study aimed to formulate, characterize and evaluate the Gliclazide (GLZ) microcapsules prepared with sodium alginate, guar gum and pectin in different ratios by ionotropic-gelation method. The microcapsules were evaluated against different parameters such as particle size and shape, Carr's index, Hausner's ratio, rheological studies and drug release kinetics. Fourier Transform Infra Red (FTIR) and Differential Scanning Calorimetric (DSC) studies demonstrated the absence of any drug - polymers interaction. Promising characteristics were observed in rheological behavior and release kinetics. The size of microcapsules and percentage yield was in the range of 676 to 727 µm and 69 to 77%, respectively. Scanning electron micrographs revealed that microcapsules were discrete, spherical and free flowing. Entrapment efficiency and uniform drug release kinetics were some of the probable characteristics depicting the novel formulation design of Gliclazide microcapsules.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600874	
Editor: 	Instituto de Tecnologia do Paraná - Tecpar	
Relação: 	10.1590/S1516-8913201402505	
Formato: 	text/html	
Fonte: 	Brazilian Archives of Biology and Technology  v.57 n.6 2014	
Fonte: 	info:eu-repo/semantics/openAccess