Data/hora: 01/06/2024 10:27:00

Provedor de dados: 	52	
País: 	Brazil	
Título: 	Methotrexate inhibits integrin adhesion molecules in the mouse model of pleurisy induced by carrageenan	
Autores: 	Dalmarco,Eduardo Monguilhott; Fröde,Tânia Silvia.	
Data: 	2007-09-01	
Ano: 	2007	
Palavras-chave: 	Methotrexate; CD11a/CD18 adhesion molecules; Leukocyte migration; Pleurisy; Mice.	
Resumo: 	The aim of this work was to analyze the effect of methotrexate (MTX) upon leukocyte migration and expression of adhesion molecules CD11a/CD18 in the lung, 4 and 48 h after inflammation induction by carrageenan in mice. The results showed that MTX significantly decreased leukocyte influx and CD11a expression in the lung at 4 and 48 h of pleurisy (P &lt; 0.01). MTX also inhibited CD18 expression at 4 h but not 48 h of pleurisy (P &lt; 0.01). These results proved that MTX at the studied doses had important anti-inflammatory properties, acting primarily on leukocyte migration from the pleural cavity to the lung via inhibition of CD11a/CD18 expression in the mouse model of inflammation.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000500005	
Editor: 	Instituto de Tecnologia do Paraná - Tecpar	
Relação: 	10.1590/S1516-89132007000500005	
Formato: 	text/html	
Fonte: 	Brazilian Archives of Biology and Technology  v.50 n.5 2007	
Fonte: 	info:eu-repo/semantics/openAccess