Data/hora: 01/06/2024 00:45:38

Provedor de dados: | 52
País: | Brazil
Título: | Antibody conjugate radioimmunotherapy of superficial bladder cancer
Autores: | Perkins,Alan; Hopper,Melanie; Murray,Andrea; Frier,Malcolm; Bishop,Mike.
Data: | 2002-09-01
Ano: | 2002
Palavras-chave: | Antibody; Radioimmunotherapy; Bladder cancer.
Resumo: | The administration of antibody conjugates for cancer therapy is now proving to be of clinical value. We are currently undertaking a programme of clinical studies using the monoclonal antibody C595 (IgG3) which reacts with the MUC1 glycoprotein antigen that is aberrantly expressed in a high proportion of bladder tumours. Radioimmunoconjugates of the C595 antibody have been produced with high radiolabelling efficiency and immunoreactivity using Tc-99m and In-111 for diagnostic imaging, and disease staging and the cytotoxic radionuclides Cu-67 and Re-188 for therapy of superficial bladder cancer. A Phase I/II therapeutic trail involving the intravesical administration of antibody directly into the bladder has now begun.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500012
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132002000500012
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.45 n.spe 2002
Fonte: | info:eu-repo/semantics/openAccess