Data/hora: 10/06/2024 15:02:46

Provedor de dados: | 52
País: | Brazil
Título: | Aqueous extract of Huang-lian induces apoptosis in lung cancer cells via P53- mediated mitochondrial apoptosis
Autores: | Zhu,Deying; Lin,Zhe; Li,Zhenzhong.
Data: | 2015-06-01
Ano: | 2015
Palavras-chave: | Huang-lian; Aqueous extract; Apoptosis.
Resumo: | The current study was designed to evaluate the activity of the aqueous extract of Huang-lian, and the main apoptosis pathway induced by the extracts of Huang-lian was detected on lung cancer. Antiproliferactive activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and TUNEL methods against human lung cancer cells (A549). Huang-lian regulated the Bcl-2 family protein-mediated mitochondrial pathway via p53 and was detected by western blot. It increased the activation of caspase-3 and caspase-3 cleavage increased as the time increased. These results suggested that Huang-lianregulated the Bcl-2 family protein-mediated mitochondrial via p53 pathway, suggesting that Huang-lian should be further investigation as a natural agent for treating and preventing cancer.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000300353
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-8913201500070
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.58 n.3 2015
Fonte: | info:eu-repo/semantics/openAccess