Data/hora: 11/06/2024 09:02:21

Provedor de dados: | 52
País: | Brazil
Título: | Embryo development alteration in rats treated with lapachol
Autores: | Maganha,Juliana; Rocha,Evelise de Souza; Brandão,Marcos Antônio Fernandes; Peters,Vera Maria; Guerra,Martha de Oliveira.
Data: | 2006-11-01
Ano: | 2006
Palavras-chave: | Lapachol; Embryo development; Rat; Reproductive toxicity.
Resumo: | Lapachol, a naphthoquinone extracted from plants of the genus Tabebuia (family Bignoneaceae), showed multiple therapeutic activities. Pregnant Wistar rats were treated with Lapachol from the 1st to the 4th (pre-implantation period) and from 5th to 7th (implantation period) post insemination day (PID). Mothers were sacrificed on the 5th or on the15th PID. Number of corpora lutea, preimplantation embryo, blastocysts, live and dead fetuses and resorptions were counted. There were no signs of maternal toxicity. The number and the morphology of embryos, during oviduct development (pre-implantation period), did not seem to be affected by this drug, but during the implantation period, lapachol was toxic causing the death of embryos and intrauterine growth retardation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000700010
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132006000700010
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.49 n.6 2006
Fonte: | info:eu-repo/semantics/openAccess