Data/hora: 07/06/2024 02:16:55

Provedor de dados: | 52
País: | Brazil
Título: | Effects of plant lectins on in vitro fibroblast proliferation
Autores: | Sell,Ana Maria; Costa,Celso Paulino da.
Data: | 2003-06-01
Ano: | 2003
Palavras-chave: | Lectins; Fibroblasts; Proliferation; MTT.
Resumo: | Lectins are carbohydrate-binding proteins that have been isolated from various sources and presented a wide spectrum of biological activities. The effects of four lectins, namely, Phaseolus vulgaris phytohemagglutinin, PHA, wheat germ agglutinin, WGA, Artocarpus integrifolia seed lectins, jacalin and artocarpin, on in vitro fibroblasts proliferation were investigated. The lectins did not influence the initial cell adhesion to the plate. PHA and WGA at 10-20 µg/mL concentrations significantly decreased fibroblasts proliferation. At these concentrations, they caused morphological alterations on cells and over 80 µg/mL, promoted cell death. Neither jacalin nor artocarpin significantly affected cell proliferation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132003000300006
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132003000300006
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.46 n.3 2003
Fonte: | info:eu-repo/semantics/openAccess