Data/hora: 01/06/2024 00:56:42

Provedor de dados: | 52
País: | Brazil
Título: | Comparison of apolipoprotein E polymorphism and other atherosclerotic risk factors in two portuguese populations: the influence of insularity
Autores: | Lopes,Paula Alexandra; Gaspar,Gisela; Napoleão,Patrícia; Santos,Maria Cristina; Pavão,Maria Leonor; Viegas-Crespo,Ana Maria.
Data: | 2007-09-01
Ano: | 2007
Palavras-chave: | Apolipoprotein E polymorphism; Cardiovascular risk factors; Atherosclerosis; Insularity.
Resumo: | The main objective of this study was to investigate the apolipoprotein (apo) E genotypes in Portuguese populations from mainland (Lisbon city) and from San Miguel Island, Azores' Archipelago (Ponta Delgada city) and to look for differences between these particular sites in apparently healthy subjects. Also, subjects with clinical diagnosis of atherosclerotic disease were investigated in San Miguel Island. In Lisbon, the genotypes distribution was: epsilon3/epsilon 3 &amp;gt; epsilon 3/epsilon 4 &amp;gt; epsilon 2/epsilon 3 &amp;gt; epsilon 4/epsilon 4 while that, for Ponta Delgada and regardless the health condition, was: epsilon 3/epsilon 3 &amp;gt; epsilon 2/epsilon 3 &amp;gt; epsilon 3/epsilon 4. Within Ponta Delgada control group, females and males had distinct genotype frequencies. The most common atherosclerotic risk factors as body mass index, blood hypertension and serum lipid parameters, presented some differences among the allelic subgroups of apo E. The major conclusions were: 1) an apparent influence of insularity in apo E polymorphism was observed; 2) both the high risk genotypes epsilon 2/epsilon 2 and epsilon 2/epsilon 4 were not found, even in patients; 3) curiously, the genotypes proportion in females was not homogenous among the three groups.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000500008
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132007000500008
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.50 n.5 2007
Fonte: | info:eu-repo/semantics/openAccess