Data/hora: 05/06/2024 02:57:01

Provedor de dados: | 52
País: | Brazil
Título: | Protective effect of sodium selenite on genotoxicity to human whole blood cultures induced by aflatoxin B1
Autores: | Geyikoglu,Fatime; Türkez,Hasan.
Data: | 2005-11-01
Ano: | 2005
Palavras-chave: | Aflatoxin B1; Selenium; Sister-chromatid exchanges; Genotoxicity; Blood.
Resumo: | The aim of this study was to investigate the effects of selenium and aflatoxin on human whole blood cultures (WBC) in relation to induction of sister-chromatid exchange (SCE). Results showed that the frequency of SCEs in peripheral lymphocytes was significantly increased by the direct-acting mutagen AFB1 (at doses 5 and 10 µM except for 1µM) compared with controls. When sodium selenite (Na2SeO3) was added at a molar ratio of 5x10-7 and 1x10-6, cells did not show significant increase in SCE frequency. Whereas, SCE rates induced by the various AFB1 concentrations could be significantly reduced by the presence of Na2SeO3 in a clear dose-related manner. These results indicated that selenite and AFB1 mutually antagonized their ability to cause DNA damage leading to the formation of SCEs. However, selenium didn't completely inhibit induction of SCEs by AFB1 compared with controls. AFB1 induced oxidative damage contributed to its genotoxicity in human WBC.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000800006
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132005000800006
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.48 n.6 2005
Fonte: | info:eu-repo/semantics/openAccess