Data/hora: 16/06/2024 15:13:03

Provedor de dados: | 52
País: | Brazil
Título: | Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
Autores: | Benvenutti,Régis Carlos; Gomes,Denise B.; Zanchet,Barbara; Locateli,Gelvani; Vechia,Cristian Alex Dalla; Zanotelli Serpa,Patrícia; Lutinski,Junir; Rodrigues Junior,Sinval Adalberto; Schönell,Amanda Patrícia; Diel,Kriptsan Abdon Poletto; Miorando,Daniela; Ernetti,Jackeline; Alves,Bianca de Oliveira; Zilli,Gabriela Adriany Lisboa; Banzato,Thais Petrochelli; Ruiz,Ana Lúcia Tasca Gois; Vidal Gutiérrez,Max; Vilegas,Wagner; Roman Junior,Walter Antônio.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | Antitumor agents; Medicinal plants; Chemical analysis.
Resumo: | Abstract Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigão. The leaves are popularly used as anti-inflammatory, antirheumatic and in the treatment of gastric disorders. However, the antiproliferative potential of this plant against human tumor cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of U. baccifera leaves extracts and fractions against a panel of human tumor cell lines in vitro besides a chemical evaluation of the most active sample by mass spectrometry (ESI-IT-MSn). The hydroalcoholic extract was inactive while dichloromethane extract showed moderate cytostatic activity against ovarian carcinoma cell line (OVCAR-3, GI50 = 1.5 μg/mL). More, the ethyl acetate and n-butanol fractions did not show important activity against tumour cell while the dichloromethane and hexane fractions showed moderate cytostatic activity against ovarian tumor cell line (OVCAR-3, GI50 = 12.7 and 9.4 μg/mL, respectively). Finally, the chemical profile evaluated by mass spectrometry (ESI-IT-MSn) allowed the detection of flavonoids in the HEU and hydroxylated fatty acid in DEU that can explain partially the biological effects observed. This is the first report of the antiproliferative effects of U. baccifera, and DEU has shown potential as a promising source of bioactive compounds.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100412
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/1678-4324-2019180531
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.62 2019
Fonte: | info:eu-repo/semantics/openAccess