Data/hora: 06/06/2024 02:26:07

Provedor de dados: | 52
País: | Brazil
Título: | Use of labelled cisplatin obtained by direct irradiation in a preliminary biodistribution study
Autores: | Carvalho Júnior,Álvaro Dutra de; Abrantes,Fabiana Moreira; Menezes,Maria Ângela; Leal,Alexandre Soares; Cardoso,Valbert Nascimento; Oliveira,Mônica Cristina de.
Data: | 2005-10-01
Ano: | 2005
Palavras-chave: | Radiolabelled cisplatin; Biodistribution; TRIGA research reactor.
Resumo: | This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, from its direct irradiation into a cadmium capsule, using the TRIGA MARK I IPR R-1 research reactor of the CDTN. The ability to detect CDDP* in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP* showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP* was taken up principally by liver, spleen and kidney. The CDDP* obtained from this condition was shown to be a good tool for biodistribution studies.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700013
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132005000700013
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.48 n.spe2 2005
Fonte: | info:eu-repo/semantics/openAccess