Data/hora: 01/06/2024 02:06:27

Provedor de dados: 	52	
País: 	Brazil	
Título: 	Use of labelled cisplatin obtained by direct irradiation in a preliminary biodistribution study	
Autores: 	Carvalho Júnior,Álvaro Dutra de; Abrantes,Fabiana Moreira; Menezes,Maria Ângela; Leal,Alexandre Soares; Cardoso,Valbert Nascimento; Oliveira,Mônica Cristina de.	
Data: 	2005-10-01	
Ano: 	2005	
Palavras-chave: 	Radiolabelled cisplatin; Biodistribution; TRIGA research reactor.	
Resumo: 	This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, from its direct irradiation into a cadmium capsule, using the TRIGA MARK I IPR R-1 research reactor of the CDTN. The ability to detect CDDP* in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP* showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP* was taken up principally by liver, spleen and kidney. The CDDP* obtained from this condition was shown to be a good tool for biodistribution studies.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700013	
Editor: 	Instituto de Tecnologia do Paraná - Tecpar	
Relação: 	10.1590/S1516-89132005000700013	
Formato: 	text/html	
Fonte: 	Brazilian Archives of Biology and Technology  v.48 n.spe2 2005	
Fonte: 	info:eu-repo/semantics/openAccess