Data/hora: 05/06/2024 18:06:15

Provedor de dados: | 52
País: | Brazil
Título: | Biodistribution of 99Mo in rats
Autores: | Souza,Raphael Sancho Sisley de; Ribeiro,Bianca da Silva; Dantas,Ana Letícia Almeida; Bernardo Filho,Mario; Dantas,Bernardo Maranhão.
Data: | 2008-12-01
Ano: | 2008
Palavras-chave: | Wistar; Molybdenum; Nuclear Medicine.
Resumo: | The modification of 99Mo standard metabolism in the presence of MDP would alter the dosimetry of this radionuclide in nuclear medicine patients. Therefore, the objective of this work is to evaluate the influence of MDP in the biodistribution of 99Mo. Wistar rats were divided in two groups of six animals, being inoculated respectively 99Molibdate and 99Mo+MDP via plex ocular. The biodistribution study was carried out after 10 and 120 minutes respectively. The organs were counted with a NaI(Tl) detector. The uptake values did not present significant differences among the groups. An in vitro study through planar chromatography was carried out to determine the affinity between molybdenum and MDP. The results show that 99Mo has low affinity both to propanone and NaCl-0.9% solution. However, 99Mo in the presence of MDP presented affinity to NaCl-0.9% solution and low affinity to propanone suggesting that 99Mo was bound to MDP under the conditions of the experiment.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700029
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132008000700029
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.51 n.spe 2008
Fonte: | info:eu-repo/semantics/openAccess