Data/hora: 05/06/2024 18:34:58

Provedor de dados: 	52	
País: 	Brazil	
Título: 	BMP4 Induces Cardiomyocyte Hypertrophy Through the Activation of ERK 1/2 Signaling Pathway in H9c2 Cells	
Autores: 	Yuan,Yu; Tao,Yezheng; Deng,Yongzhi; Ye,Qunhui; Lin,Bin; Wu,Lin.	
Data: 	2019-01-01	
Ano: 	2019	
Palavras-chave: 	BMP4; Myocardial hypertrophy; ERK1/2 signaling pathway.	
Resumo: 	Abstract Bone morphogenetic protein-4 (BMP4) is a member of the bone morphogenetic protein family which plays an important role in bone formation, inflammation and cardiac hypertrophy. The aim of this study was to investigate the underlying molecular mechanism that BMP4-induced cardiomyocyte hypertrophy. H9c2 cells were used to measure cell surface area and protein synthesis. Western blot was used to examine hypertrophic marker brain natriuretic peptide (BNP) protein expression and phosphorylation of ERK1/2. The results exhibited that cell surface area, protein synthesis and BNP protein expression were increased with BMP4 treatment. While PD98059 inhibited these effects of BMP4. In addition, BMP4 treatment increased phosphorylation of ERK1/2 in a time- and dose-dependent manner. PD98059 treatment decreased phosphorylation of ERK1/2 that was increased by BMP4. These results suggest that BMP4 induces cardiomyocyte hypertrophy through the activation of ERK1/2 cell signaling pathway.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100315	
Editor: 	Instituto de Tecnologia do Paraná - Tecpar	
Relação: 	10.1590/1678-4324-2019180699	
Formato: 	text/html	
Fonte: 	Brazilian Archives of Biology and Technology  v.62 2019	
Fonte: 	info:eu-repo/semantics/openAccess