Data/hora: 05/06/2024 12:09:23

Provedor de dados: | 52
País: | Brazil
Título: | Acetylsalicylic acid and labeling of blood constituents with technetium-99m
Autores: | Fonseca,Adenilson de Souza da; Frydman,Jacques Natan Grinapel; Rocha,Vanessa Câmara da; Bernardo-Filho,Mario.
Data: | 2005-10-01
Ano: | 2005
Palavras-chave: | Acetylsalicylic Acid; Blood Constituents; Technetium-99m.
Resumo: | Acetylsalicylic acid is the drug most used an anti-inflammatory agent and for secondary prevention of thrombotic phenomenon. Drugs can modify the labeling of blood constituents with technetium-99m (99mTc). The aim of this work was to evaluate the effect of in vitro or in vivo assays with acetylsalicylic acid on the labeling of the blood constituents with 99mTc. In vitro assay was performed with samples of whole blood from Wistar rats incubated with acetylsalicylic acid (1.0 mg/ml) for one hour before the 99mTc-labeling process. For in vivo assay, Wistar rats were treated with acetylsalicylic acid (1.5 mg/kg) during one hour, and the whole blood was withdrawn for the 99mTc-labeling process. Saline was used in control groups. Data showed that the fixation of 99mTc to the blood constituents was not significantly (p&gt;0.05) modified in in vitro and in vivo assays with acetylsalicylic acid, at least not when the experiments were carried out with the doses normally used in human beings.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700024
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132005000700024
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.48 n.spe2 2005
Fonte: | info:eu-repo/semantics/openAccess