Data/hora: 12/06/2024 07:05:24

Provedor de dados: | 55
País: | Brazil
Título: | Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit
Autores: | Dizbay,Murat; Kalkanci,Ayse; Sezer,Busra Ergut; Aktas,Firdevs; Aydogan,Sibel; Fidan,Isil; Kustimur,Semra; Sugita,Takashi.
Data: | 2008-10-01
Ano: | 2008
Palavras-chave: | Candidemia; Candida parapsilosis; Nosocomial outbreak; Intensive care unit; RAPD; DNA sequencing.
Resumo: | We investigated a nosocomial cluster of four Candida parapsilosis fungemia episodes that occurred in a neurological intensive care unit over a two-week period. The four infected patients had received parenteral nutrition through central lines, and all four had catheter-related candidemia. All of the isolates were susceptible to all of the antifungals tested, including amphotericin B, fluconazole, voriconazole, and caspofungin. They had strictly related fingerprints, based on randomly amplified polymorphic DNA analysis. Additional DNA sequencing data revealed that they were same strain. Although no isolate of Candida parapsilosis was recovered from other clinical, surveillance, or environmental samples, nosocomial spread of this yeast ceased, following the reinforcement of infection-control measures. Candida parapsilosis may require an intravascular foreign body to cause fungemia, but this outbreak shows that it can be transmitted nosocomially and can cause epidemics.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500010
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702008000500010
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.12 n.5 2008
Fonte: | info:eu-repo/semantics/openAccess