Data/hora: 01/06/2024 06:24:53

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Evaluation of reactive Epstein-Barr virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS)	
Autores: 	Ramroodi,Nourollah; Niazi,Abbas Ali; Sanadgol,Nima; Ganjali,Zohre; Sarabandi,Vida.	
Data: 	2013-04-01	
Ano: 	2013	
Palavras-chave: 	EBV; MS; Reactivation; QPCR; ELISA.	
Resumo: 	OBJECTIVES: Epstein-Barr virus has been recently associated with the onset of multiple sclerosis, yet understanding how it elicits autoimmunity remains elusive. We investigated the relation between Epstein-Barr virus reactivation and disease development in different subtypes of multiple sclerosis. METHODS: In the present research, we have determined the Epstein-Barr virus-DNA load by quantitative real-time polymerase chain reaction and Epstein-Barr virus antibody levels by EIA technique in both multiple sclerosis patients (n = 78) and healthy controls (n = 123). RESULTS: Our results demonstrated increased titer of both anti-Epstein-Barr virus-IgG and IgM antibodies in patients (91.02% vs 82.11% in controls, p &lt; 0.001 and 14.1% vs 4.06% in controls, p &lt; 0.001, respectively). Overall, Epstein-Barr virus reactivation was found in 68.75% of subtypes of multiple sclerosis, 4.54% of multiple sclerosis primary subtype, and in only 3.25% of healthy control subjects. Moreover, in samples of patients with disease relapse (exacerbation) cell free viral DNA was elevated in contrast to other patients (p &lt; 0.001). CONCLUSIONS: These findings provide further support for the detrimental effects of Epstein- Barr virus in the reactivation of multiple sclerosis attacks.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200007	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2012.09.008	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.17 n.2 2013	
Fonte: 	info:eu-repo/semantics/openAccess