Data/hora: 06/06/2024 06:41:23

Provedor de dados: | 55
País: | Brazil
Título: | Evaluation of reactive Epstein-Barr virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS)
Autores: | Ramroodi,Nourollah; Niazi,Abbas Ali; Sanadgol,Nima; Ganjali,Zohre; Sarabandi,Vida.
Data: | 2013-04-01
Ano: | 2013
Palavras-chave: | EBV; MS; Reactivation; QPCR; ELISA.
Resumo: | OBJECTIVES: Epstein-Barr virus has been recently associated with the onset of multiple sclerosis, yet understanding how it elicits autoimmunity remains elusive. We investigated the relation between Epstein-Barr virus reactivation and disease development in different subtypes of multiple sclerosis. METHODS: In the present research, we have determined the Epstein-Barr virus-DNA load by quantitative real-time polymerase chain reaction and Epstein-Barr virus antibody levels by EIA technique in both multiple sclerosis patients (n = 78) and healthy controls (n = 123). RESULTS: Our results demonstrated increased titer of both anti-Epstein-Barr virus-IgG and IgM antibodies in patients (91.02% vs 82.11% in controls, p &lt; 0.001 and 14.1% vs 4.06% in controls, p &lt; 0.001, respectively). Overall, Epstein-Barr virus reactivation was found in 68.75% of subtypes of multiple sclerosis, 4.54% of multiple sclerosis primary subtype, and in only 3.25% of healthy control subjects. Moreover, in samples of patients with disease relapse (exacerbation) cell free viral DNA was elevated in contrast to other patients (p &lt; 0.001). CONCLUSIONS: These findings provide further support for the detrimental effects of Epstein- Barr virus in the reactivation of multiple sclerosis attacks.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200007
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2012.09.008
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.17 n.2 2013
Fonte: | info:eu-repo/semantics/openAccess