Data/hora: 07/06/2024 04:44:33

Provedor de dados: | 55
País: | Brazil
Título: | A non-randomized comparative study using different doses of acyclovir to prevent herpes simplex reactivation in patients submitted to autologous stem cell transplantation
Autores: | Atalla,Angelo; Maiolino,Angelo; Guimarães,Maria Angélica; Guimarães,Antonio Carlos; Nucci,Marcio.
Data: | 2005-08-01
Ano: | 2005
Palavras-chave: | Acyclovir; Prophylaxis; Stem cell transplantation.
Resumo: | The reactivation of Herpes Simplex virus (HSV) occurs in 70% to 80% of patients submitted to autologous stem cell transplantation (ASCT); it increases the severity of chemotherapy-induced mucositis. Therefore, the use of acyclovir in ASCT patients is considered standard practice. However, the minimum dose needed to prevent reactivation is a matter of debate. We compared two doses of acyclovir in a non-randomized fashion in 59 patients submitted to ASCT: 32 patients received a dose of 125 mg/m² IV every six hours and the subsequent 27 patients received a dose of 60 mg/m² IV every six hours. Viral excretion was evaluated through weekly viral culture of oral swabs. Grade 4 mucositis was more frequent in Group 1 (p= 0.03). The reactivation rates in Groups 1 and 2 were 9% and 4%, respectively (p= 0.62, 95% confidence interval -7 - 18). Prophylaxis with reduced doses of intravenous acyclovir seems to be as effective as a higher dose in inhibiting HSV reactivation, with a significant reduction in cost. Prospective randomized studies are needed to confirm our conclusions.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400010
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702005000400010
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.9 n.4 2005
Fonte: | info:eu-repo/semantics/openAccess