Data/hora: 06/06/2024 11:23:33

Provedor de dados: | 55
País: | Brazil
Título: | Short-interfering RNAs as antivirals against rabies
Autores: | Brandão,Paulo Eduardo; Castilho,Juliana Galera; Fahl,Willian; Carnieli Jr.,Pedro; Oliveira,Rafael de Novaes; Macedo,Carla Isabel; Carrieri,Maria Luiza; Kotait,Ivanete.
Data: | 2007-04-01
Ano: | 2007
Palavras-chave: | SiRNA; Rabies; Antiviral.
Resumo: | This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200011
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702007000200011
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.11 n.2 2007
Fonte: | info:eu-repo/semantics/openAccess