Data/hora: 16/06/2024 00:57:39

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Identifying risk factors of immune reconstitution inflammatory syndrome in AIDS patients receiving highly active anti-retroviral therapy	
Autores: 	He,Bo; Zheng,Yuhuang; Liu,Meng; Zhou,Guoqiang; Chen,Xia; Mamadou,Diallo; He,Yan; Zhou,Huaying; Chen,Zi.	
Data: 	2013-04-01	
Ano: 	2013	
Palavras-chave: 	IRIS; AIDS; HIV; HAART.	
Resumo: 	Immune reconstitution inflammation syndrome typically occurs within days after patients undergo highly active anti-retroviral therapy and is a big hurdle for effective treatment of AIDS patients. In this study, we monitored immune reconstitution inflammation syndrome occurrence in 238 AIDS patients treated with highly active anti-retroviral therapy. Among them, immune reconstitution inflammation syndrome occurred in 47 cases (19.7%). Immune reconstitution inflammation syndrome patients had significantly higher rate of opportunistic infection (p &lt; 0.001) and persistently lower CD4+ cell count (p &lt; 0.001) compared to the non-immune reconstitution inflammation syndrome patients. In contrast, no significant differences in HIV RNA loads were observed between the immune reconstitution inflammation syndrome group and non-immune reconstitution inflammation syndrome group. These data suggest that a history of opportunistic infection and CD4+ cell counts at baseline may function as risk factors for immune reconstitution inflammation syndrome occurrence in AIDS patients as well as potential prognostic markers. These findings will improve the management of AIDS with highly active anti-retroviral therapy.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200009	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2012.10.014	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.17 n.2 2013	
Fonte: 	info:eu-repo/semantics/openAccess