Data/hora: 11/06/2024 04:42:19

Provedor de dados: | 55
País: | Brazil
Título: | Epidemiology of Clostridium difﬁcile: a hospital-based descriptive study in Argentina and Mexico
Autores: | Lopardo,Gustavo; Morﬁn-Otero,Rayo; Moran-Vazquez,Iliana Isabel; Noriega,Fernando; Zambrano,Betzana; Luxemburger,Christine; Foglia,Ginamarie; Rivas,Enrique Eduardo.
Data: | 2015-02-01
Ano: | 2015
Palavras-chave: | Clostridium infections; Epidemiology; Latin America; Incidence.
Resumo: | A prospective study was conducted in four tertiary hospitals in Argentina and Mexico in order to describe the occurrence of Clostridium difﬁcileinfection (CDI) in these settings. The objective was to evaluate the incidence of CDI in at-risk populations in Argentina (one center) and Mexico (three centers) and to further explore potential study sites for vaccine development in this region. A prospective, descriptive, CDI surveillance study was conducted among hospitalized patients aged ≥40 years who had received ≥48 h of antibiotic treatment. Stool samples were collected from those with diarrhea within 30 days after starting antibiotics and analyzed for toxins A and B by ELISA, and positive samples were further tested by toxinogenic culture and restriction endonuclease analysis type assay. Overall, 466 patients were enrolled (193 in Argentina and 273 in Mexico) of whom 414 completed the follow-up. Of these, 15/414 (3.6%) experienced CDI episodes occurring on average 18.1 days after admission to hospital and 15.9 days after the end of antibiotics treatment. The incidence rate of CDI was 3.1 (95% CI 1.7-5.2) per 1000 patient-days during hospitalization, and 1.1 (95% CI 0.6-1.8) per 1000 patient-days during the 30-day follow-up period. This study highlighted the need for further evaluation of the burden of CDI in both countries, including the cases occurring after discharge from hospital.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100008
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2014.07.004
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.19 n.1 2015
Fonte: | info:eu-repo/semantics/openAccess