Data/hora: 06/06/2024 07:35:30

Provedor de dados: | 55
País: | Brazil
Título: | In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of Candida dubliniensis
Autores: | Scheid,Liliane Alves; Mario,Débora Alves Nunes; Kubiça,Thaís Felli; Santurio,Janio Morais; Alves,Sydney Hartz.
Data: | 2012-02-01
Ano: | 2012
Palavras-chave: | Candida Antifungal agents Fluconazole Drug resistance; Fungal.
Resumo: | In the present study we used two groups of Candida dubliniensis strains: one containing fluconazole-susceptible clinical isolates and another containing fluconazole-resistant laboratory derivative from the former to examine the changes on susceptibility accompanying the development of resistance to fluconazole. Our findings confirmed the ability of C. dubliniensis isolates to become resistant to fluconazole and indicated that this resistance was crossed with ketoconazole, itraconazole, ravuconazole and terbinafine. We also tested combinations of terbinafine, amphotericin B, itraconazole and voriconazole against both groups of isolates in a checkerboard assay. Surprisingly, most combinations evidenced indifferent interactions, and the best synergism appeared when terbinafine and itraconazole were combined against the fluconazole-resistant group.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100014
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702012000100014
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.16 n.1 2012
Fonte: | info:eu-repo/semantics/openAccess