Data/hora: 03/06/2024 08:17:43

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk	
Autores: 	Guimarães,Milena Maria Moreira; Greco,Dirceu Bartolomeu; Moreira,Allyson Nogueira; Guimarães,Nathalia Sernizon; Freire,Cláudia Maria Vilas; Rohlfs,Bruna Guimarães; Machado,Lucas José de Campos.	
Data: 	2018-06-01	
Ano: 	2018	
Palavras-chave: 	HIV; Hyperlipidemia; Atherosclerosis; Lipid accumulation product index; Cardiovascular risk; Insulin resistance.	
Resumo: 	ABSTRACT The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels. Body mass index (BMI) was similar in both groups; however, waist circumference was greater in the HIV-infected patients. Triglyceride levels were significantly higher (p &lt; 0.001) and HDL cholesterol levels were lower in HIV-infected patients (p &lt; 0.001). Plasma glucose (p = 0.01) and insulin (p = 0.005) levels two hours after a glucose load, HOMA-IR index (p &lt; 0.001) and LAP index (p &lt; 0.001) were higher in the HIV-infected patients. A positive and significant correlation was found between HOMA-IR index and LAP (r = 0.615; p &lt; 0.01), BMI (r = 0.334; p &lt; 0.01) and waist circumference (r = 0.452; p &lt; 0.01) in the HIV-infected patients. In male HIV-infected patients and controls, ROC curve analyses revealed that the best cut-off value of LAP to define the presence of insulin resistance was 64.8 (sensitivity 86%, specificity 77% and area under the curve 0.824). These results confirm that insulin resistance is more common in HIV-patients on antiretroviral drugs than in HIV-negative controls. A positive and significant correlation was found between the LAP index and the HOMA index, with LAP ≥ 64.8 constituting an additional risk factor for cardiovascular disease in male HIV patients.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300171	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2018.03.006	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.22 n.3 2018	
Fonte: 	info:eu-repo/semantics/openAccess