Data/hora: 09/06/2024 11:48:42

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis	
Autores: 	Cordeiro,Cynthia Azeredo; Vieira,Erica Leandro Marciano; Rocha,Natália Pessoa; Castro,Vinicius Monteiro; Oréfice,Juliana Lambert; Barichello,Tatiana; Costa,Rogerio Alves; Oréfice,Fernando; Young,Lucy; Teixeira,Antonio Lucio.	
Data: 	2017-03-01	
Ano: 	2017	
Palavras-chave: 	Retinochoroiditis; Toxoplasma gondii; Brain-derived neurotrophic factor.	
Resumo: 	Abstract Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment.  Methods: Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay.  Results: BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors.  Conclusion: BDNF may be released in the context of the active TR inflammatory response.	
Tipo: 	Info:eu-repo/semantics/other	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200176	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2016.11.005	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.21 n.2 2017	
Fonte: 	info:eu-repo/semantics/openAccess