Data/hora: 13/06/2024 02:13:48

Provedor de dados: | 55
País: | Brazil
Título: | Progress towards meningitis prevention in the conjugate vaccines era
Autores: | Laval,Cristina Aparecida Borges; Pimenta,Fabiana Cristina; Andrade,João Guimarães de; Andrade,Soraya S.; Andrade,Ana Lucia S. S. de.
Data: | 2003-10-01
Ano: | 2003
Palavras-chave: | Conjugate vaccines; Hib conjugate vaccine; Pneumococcal conjugate vaccine; Meningococcal conjugate vaccine; Impact of Hib conjugate vaccine.
Resumo: | Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500006
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702003000500006
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.7 n.5 2003
Fonte: | info:eu-repo/semantics/openAccess