Data/hora: 01/06/2024 01:40:38

Provedor de dados: | 55
País: | Brazil
Título: | Imbalance of Th17 and Treg in peripheral blood mononuclear cells of active tuberculosis patients
Autores: | Luo,Jie; Zhang,Mingxu; Yan,Baosong; Zhang,Kejun; Chen,Ming; Deng,Shaoli.
Data: | 2017-03-01
Ano: | 2017
Palavras-chave: | Active tuberculosis; Th17; Treg; IL-17; IL-10.
Resumo: | Abstract  Objective: Maintaining a right balance between Th17 and Treg might be critical to the immunopathogenesis of active tuberculosis (TB). This study aimed to assess whether the Th17/Treg balance is altered in active TB patients.  Methods: 250 study subjects (90 active TB patients, 80 latent TB subjects, and 80 healthy controls) were recruited for the study. The expression of Th17 and Treg in peripheral blood mononuclear cells (PBMCs) in the 250 subjects was investigated by flow cytometry. Plasma levels of cytokines IL-17 and IL-10, which are related to Th17 and Treg, respectively, were determined by ELISA.  Results: The percentages of Th17 and Treg in PBMCs from active TB patients were significantly higher than those from latent TB or control groups (Th17: 4.31 ± 1.35% vs. 1.58 ± 0.71% or 1.15 ± 0.49%, p &lt; 0.05; Treg: 11.44 ± 2.69% vs. 7.54 ± 1.56% or 4.10 ± 0.99%, p &lt; 0.05). The expression of IL-17 and IL-10 was significantly increased in active TB patients in comparison to that in latent TB or control groups (IL-17: 16.85 ± 9.68 vs. 7.23 ± 5.19 or 8.21 ± 5.51 pg/mL, p &lt; 0.05; IL-10: 28.70 ± 11.27 vs. 20.25 ± 8.57 or 13.94 ± 9.00 pg/mL, p &lt; 0.05).  Conclusions: Our study demonstrated an altered balance of Treg/Th17 in active TB patients, with higher percentages of Th17 and Treg in PBMCs. Further research on this imbalance may offer a new direction for TB treatment.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200155
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2016.10.011
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.21 n.2 2017
Fonte: | info:eu-repo/semantics/openAccess