Data/hora: 06/06/2024 17:20:33

Provedor de dados: | 55
País: | Brazil
Título: | Trypanosoma cruzi: analysis of two different strains after piplartine treatment
Autores: | Vieira,Gabriela Alves Licursi; Silva,Marco Túlio Alves da; Regasini,Luis Octávio; Cotinguiba,Fernando; Laure,Helen Julie; Rosa,José César; Furlan,Maysa; Cicarelli,Regina Maria Barretto.
Data: | 2018-06-01
Ano: | 2018
Palavras-chave: | Trypanosomatids; Proteome; Piplartine; Therapeutic targets.
Resumo: | ABSTRACT The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas' disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effective during the chronic phase. Therefore, it is extremely urgent to find innovative chemotherapeutic agents and/or effective vaccines. Since piplartine has several biological activities, including trypanocidal activity, the present study aimed to evaluate it on two T. cruzi strains proteome. Considerable changes in the expression of some important enzymes involved in parasite protection against oxidative stress, such as tryparedoxin peroxidase (TXNPx) and methionine sulfoxide reductase (MSR) was observed in both strains. These findings suggest that blocking the expression of the two enzymes could be potential targets for therapeutic studies.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300208
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2018.02.009
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.22 n.3 2018
Fonte: | info:eu-repo/semantics/openAccess