Data/hora: 11/06/2024 00:45:59

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Hybrid capture as a tool for cervical lesions screening in HIV-infected women: insights from a Brazilian cohort	
Autores: 	Jalil,Emilia Moreira; Luz,Paula M.; Quintana,Marcel; Friedman,Ruth Khalili; Madeira,Rosa M. Domingues S.; Andrade,Angela Cristina; Chicarino,Janice; Moreira,Ronaldo Ismerio; Derrico,Monica; Levi,José Eduardo; Russomano,Fabio; Veloso,Valdilea Gonçalves; Grinsztejn,Beatriz.	
Data: 	2018-01-01	
Ano: 	2018	
Palavras-chave: 	HPV; HIV; Women; Cohort; Incidence.	
Resumo: 	ABSTRACT  Introduction: Cervical cancer remains an important burden for HIV-infected women in the era of combination antiretroviral therapy. Recommendations for cervical screening in these women diverge and may include high-risk HPV (HRHPV) testing. We aimed to evaluate the clinical usefulness of a single HRHPV testing for cervical screening of HIV-infected women.  Methods: 723 HIV-infected women from a Brazilian prospective cohort were included between 1996 and 2012. Inclusion criteria were: normal cervical cytology at baseline and having a HRHPV-test at baseline. We calculated incidence rates of any squamous intraepithelial lesion (SIL) and high grade SIL+ (HSIL+) and negative predictive values (NPV) within 12 and 36 months. Hazard Ratios were obtained using Cox proportional hazards regression models.  Results: Incidence rate for both outcomes was low (9.9 cases per 100 PY [95% CI 8.8–11.0] for any SIL and 1.3 cases per 100 PY [95% IC 0.9–1.8] for HSIL+). Women with a HRHPV positive status at baseline had 1.7-fold (95% CI 1.3–2.2) and 3.2-fold (95% CI 1.5–7.1) increased risk of presenting any SIL and HSIL+, respectively, during follow-up. Negative-HRHPV test presented high NPV for both periods and outcomes (any SIL: 92.4% [95% CI 89.7–94.6] for 12 months and 80.9% [95% CI 77.2–84.3] for 36 months; and HSIL+: 99.8% [95% CI 98.9–100.0] for 12 months and 99.0 [95% CI 97.6–99.7] for 36 months).  Conclusions: Incidence of any and high grade cytological abnormality was significantly higher among HIV-infected women with positive-HRHPV test. A single negative-HRHPV test helped reassure follow-up free of cytological abnormalities through three years of follow-up in HIV-infected women with negative cytology.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100016	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2017.10.007	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.22 n.1 2018	
Fonte: 	info:eu-repo/semantics/openAccess