Data/hora: 09/06/2024 06:27:16

Provedor de dados: | 55
País: | Brazil
Título: | An in vivo test to assess mefloquine 25 mg/kg for the treatment of uncomplicated falciparum malaria in Rondônia, Brazil
Autores: | Basano,S.A.; Bianco,A.; Taylor,W.R..J; Olliaro,P.; Camargo,L.M.A.
Data: | 2006-08-01
Ano: | 2006
Palavras-chave: | Malaria; Mefloquine; Amazon; Rondônia; Therapeutics.
Resumo: | Drug-resistant Plasmodium falciparum is undermining malaria control efforts worldwide. In Brazil, mefloquine (MQ) at a dose of 15 mg/kg body weight is used to treat P. falciparum. At this dose, MQ resistance developed rapidly in Thailand. Use of a higher MQ dose may retard the development of resistance. We treated 50 patients aged one to 67 years who had acute, uncomplicated P falciparum malaria using MQ 25 mg/kg. There were no serious adverse events. Two patients complained of dizziness and insomnia. Assessing evaluable patients, the day 42 cure rate was 40/42 [95.2% (95% confidence interval 83.8 to 99.4%)]. Mefloquine was efficacious and well tolerated in this small cohort from the state of Rôndonia.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400013
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702006000400013
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.10 n.4 2006
Fonte: | info:eu-repo/semantics/openAccess