Data/hora: 11/06/2024 09:11:55

Provedor de dados: | 55
País: | Brazil
Título: | Apoptosis and progression of hepatic fibrosis in hepatitis C patients
Autores: | Schinoni,Maria Isabel; Paraná,Raymundo; Cavalcante,Daniel.
Data: | 2006-04-01
Ano: | 2006
Palavras-chave: | Apoptosis; Hepatitis C; Liver fibrosis.
Resumo: | Hepatitis C is a worldwide endemic disease, affecting roughly 200 million people. It has a variable prognosis, depending on the progression to fibrosis. During the last five years, the importance of apoptosis for the pathogenesis of various diseases, including hepatitis, has been recognized. It has been suggested that an increase in T cell-apoptosis during a hepatitis C virus infection is the cause of impaired regulation of the immune cellular response, helping to maintain infection. Thus, the interest in discovering the probable mechanisms by which the hepatitis C virus perpetuates in the liver, and to determine the conditions that predispose for progression of this disease, makes investigation of apoptosis in hepatic injury of great interest. We have made an overview of the various mechanisms by which the cell, more specifically the hepatic cell, is affected by apoptosis, and how it interacts with the hepatitis C virus and the immune system.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200009
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702006000200009
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.10 n.2 2006
Fonte: | info:eu-repo/semantics/openAccess