Data/hora: 05/06/2024 18:27:26

Provedor de dados: | 55
País: | Brazil
Título: | FilmArray Meningitis/Encephalitis (ME) panel in the diagnosis of bacterial meningitis
Autores: | Domingues,Renan Barros; Santos,Márcio Vega dos; Leite,Fernando Brunale Vilela de Moura; Senne,Carlos.
Data: | 2019-12-01
Ano: | 2019
Palavras-chave: | Meningitis; FilmArray Meningitis/Encephalitis; Cerebrospinal fluid; Polymerase chain reaction.
Resumo: | ABSTRACT The precise diagnosis of bacterial meningitis is essential. Cytological and biochemical examination of cerebrospinal fluid (CSF) are not specific. Conventional methods for bacterial meningitis lack sensitivity or take too long for a final result. Therefore, other methods for rapid and accurate diagnosis of central nervous system infections are required. FilmArray meningitis/encephalitis (ME) panel is a PCR multiplex for simultaneous and rapid identification of 14 pathogens, including 6 bacteria, 7 viruses, and Cryptococcus. We evaluated 436 CSF samples submitted to FilmArray ME Panel. Among them, 25 cases were positive for bacteria, being Streptococcus pneumonia the most frequent (48 %). Among positive cases for bacteria, 60 % were positive only with FilmArray. All the bacterial meningitis cases in which the only positive test was FilmArray had CSF findings suggestive of bacterial meningitis, including neutrophilic pleocytosis, increased CSF protein and lactate, and decreased CSF glucose. These findings suggest that FilmArray may increase the diagnostic sensitivity for bacterial meningitis.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600468
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2019.10.008
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.23 n.6 2019
Fonte: | info:eu-repo/semantics/openAccess