Data/hora: 09/06/2024 03:41:48

Provedor de dados: | 55
País: | Brazil
Título: | Double-dose hepatitis B vaccination in cirrhotic patients on a liver transplant waiting list
Autores: | Bonazzi,Patricia R.; Bacchella,Telesforo; Freitas,Angela C.; Osaki,Karina T.; Lopes,Marta H.; Freire,Maristela P.; Machado,Marcel C.C.; Abdala,Edson.
Data: | 2008-08-01
Ano: | 2008
Palavras-chave: | Vaccine; Cirrhotic; Hepatitis B; Liver transplant.
Resumo: | Development of immunity to hepatitis B virus in cirrhotic patients waiting for liver transplantation is highly desirable. Though a double-dose regimen is available, little is know about its effectiveness. We examined the efficacy of double-dose hepatitis B virus vaccination in cirrhotic patients waiting for liver transplantation. We studied 43 patients who were waiting for liver transplantation. They were vaccinated with three doses of 40 mg hepatitis B vaccine at 0, 1 and 6 months; the normal dose is 20 mg. Efficacy was measured based on seroconversion of anti-HBs. Global response to the primary vaccination scheme was 67.5% (29 patients). Forty-one per cent of responders had anti-HBs titers above 1,000 IU/mL. No factors were associated with response, based on multivariate analysis. The vaccination scheme of 40 mg at 0, 1 and 6 months was superior to conventional vaccination doses (20 mg) for cirrhotic patients on a waiting list for liver transplantation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400009
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702008000400009
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.12 n.4 2008
Fonte: | info:eu-repo/semantics/openAccess