Data/hora: 10/06/2024 14:58:20

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Thermotolerance of Histoplasma capsulatum at 40 °C predominates among clinical isolates from different Latin American regions	
Autores: 	Sahaza,Jorge H.; Rodríguez-Arellanez,Gabriela; Canteros,Cristina E.; Reyes-Montes,María del Rocío; Taylor,Maria Lucia.	
Data: 	2020-02-01	
Ano: 	2020	
Palavras-chave: 	Latin America; H. capsulatum; Yeasts; Thermotolerance; Thermosensitivity.	
Resumo: 	ABSTRACT The yeast phase of 22 Histoplasma capsulatum clinical isolates from Mexico, Argentina, Colombia, and Guatemala and three reference strains, one from Panama and two from the United States of America (USA), were screened for thermosensitivity characteristics using different analyses. Growth curves at 0, 3, 6, 12, 24, and 30 h of incubation at 37 and 40 °C, the growth inhibition percentage at 40 °C, and the doubling time at 37 and 40 °C were determined for all yeasts studied. Most of the isolates examined exhibited thermotolerant phenotypes at 40 °C, whereas a thermosensitive phenotype at 40 °C was only detected in the Downs reference strain from the USA. Growth inhibition values lower than 33.8% supported the predominance of the thermotolerant phenotype at 40 °C. The doubling time means found for the different isolates were 5.14 h ± 1.47 h at 37 °C and 5.55 h ± 1.87 h at 40 °C. This is the first report to underscore the predominance of thermotolerant and delayed doubling time phenotypes in H. capsulatum clinical isolates from different regions of Latin America.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100044	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1016/j.bjid.2019.12.007	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.24 n.1 2020	
Fonte: 	info:eu-repo/semantics/openAccess