Data/hora: 06/06/2024 04:32:39

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil	
Autores: 	Mendes-Corrêa,Maria Cassia Jacintho; Bittar,Roseli Saraiva Moreira; Salmito,Norma; Oiticica,Jeanne.	
Data: 	2011-02-01	
Ano: 	2011	
Palavras-chave: 	Hepatitis C; Chronic; Hearing loss; Sudden; Interferon-alpha.	
Resumo: 	Sudden hearing loss is defined as a sensorineural hearing loss, equal to or greater than 30 dB, at three or more consecutive frequencies, which takes place within 72 hours. Both peginterferon and ribavirin are well-known to be associated with significant adverse effects, but sudden hearing loss is uncommon. We report a 65-year-old male patient who developed sudden-onset hearing loss during combination therapy with pegylated interferon-alpha and ribavirin for chronic hepatitis C. Peginterferon and ribavirin may cause sudden hearing loss that may not recover after discontinuation of therapy. Immediate treatment for all possible etiologies is essential, along with targeted investigations and early referral for an Ear, Nose and Throat specialist. Physicians should be aware of the possible ototoxic effects of peginterferon and ribavirin combination therapy requiring appropriate surveillance.	
Tipo: 	Info:eu-repo/semantics/report	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100017	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702011000100017	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.15 n.1 2011	
Fonte: 	info:eu-repo/semantics/openAccess