Data/hora: 03/06/2024 05:43:08

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Galactomannan detection from piperacillin-tazobactam brands available in the Brazilian market	
Autores: 	Xavier,Melissa Orzechowski; Pasqualotto,Alessandro Comarú; Aquino,Valério Rodrigues; Sukiennik,Teresa Cristina Teixeira; Severo,Luiz Carlos.	
Data: 	2009-10-01	
Ano: 	2009	
Palavras-chave: 	Piperacillin-tazobactam; Aspergillosis; Platelia Aspergillus; Galactomannan.	
Resumo: 	Piperacillin-tazobactam is a broad spectrum antimicrobial agent that can cause false-positive results in the commercial Platelia Aspergillus EIA test. So far, no study has been performed in Latin America to evaluate the clinical implication of this finding. Here we studied the potential for galactomannan detection in piperacillin-tazobactam batches commercialized in the Brazilian market. Five batches from distinct laboratories were tested in duplicate in the Platelia Aspergillus EIA according to the manufacturer's instructions. Only one drug showed crossreaction at a cut-off of 0.5. Human serum was spiked with this particular drug aiming to mimic achievable piperacillin-tazobactam concentrations in the serum. Results were all negative for galactomannan detection, even at high drug concentrations. Results from this pilot study suggest that piperacillin-tazobactam might not be a clinically significant cause of false-positive results in the Platelia Aspergillus EIA test in Brazil.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500007	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702009000500007	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.13 n.5 2009	
Fonte: 	info:eu-repo/semantics/openAccess