Data/hora: 06/06/2024 00:50:08

Provedor de dados: | 55
País: | Brazil
Título: | Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil
Autores: | Vieira,José Luiz Fernandes; Borges,Larissa Maria Guimarães; Nascimento,Margareth Tavares Silva; Gomes,Andreza de L.S.
Data: | 2008-10-01
Ano: | 2008
Palavras-chave: | Falciparum malaria; Quinine; Treatment.
Resumo: | We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500001
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702008000500001
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.12 n.5 2008
Fonte: | info:eu-repo/semantics/openAccess