Data/hora: 05/06/2024 04:32:58

Provedor de dados: | 55
País: | Brazil
Título: | Klebsiella ESBL bacteremia-mortality and risk factors
Autores: | Tuon,Felipe Francisco; Kruger,Margot; Terreri,Marcos; Penteado-Filho,Sergio R; Gortz,Lucas.
Data: | 2011-12-01
Ano: | 2011
Palavras-chave: | Klebsiella pneumoniae; Beta-lactamases; Bacteremia; Carbapenems.
Resumo: | Background: Extended spectrum β-lactamase (ESBL)-producing bacteria have become recognized as a problem in South America. The aim of this study was to evaluate risk factors and mortality rate in bacteremia caused by ESBL-producing Klebsiella pneumoniae in a Brazilian hospital. Methods: A three-year retrospective cohort study with 104 cases of K. pneumoniae bacteremia (61 ESBL and 43 non-ESBL). Several clinical and laboratory variables were evaluated. The outcome of interest was 30-day mortality. The adequate treatment was evaluated according to antibiotic susceptibility. Results: Multivariable analysis showed that central venous catheter and mechanical ventilation were independent risk factors for ESBL. The duration of hospitalization before the bacteremia was not a risk factor. Mortality was similar in ESBL and non-ESBL and inadequate therapy was not shown to be a risk factor. Conclusion: ESBL-producing Klebsiella bacteremia can occur early, suggesting that a carbapenem should be included in the initial empirical therapy for bacteremia in patients under mechanical ventilation and/or central venous catheter in our institution.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600016
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702011000600016
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.15 n.6 2011
Fonte: | info:eu-repo/semantics/openAccess