Data/hora: 11/06/2024 12:01:44

Provedor de dados: | 55
País: | Brazil
Título: | Compositional changes of PBL population in patients with chronic hepatitis B virus infection
Autores: | Alireza,Khabiri; Mohsen,Abolhassani; Sudabeh,Aslani; Hiedeh,Darabi; Farideh,Bagheri; Mohammad-Hossein,Alimohammadian.
Data: | 2001-12-01
Ano: | 2001
Palavras-chave: | Hepatitis B virus; Chronic HBV infection; HBsAg; HBeAg; HBeAb; Lymphocyte subset; Flow cytometry.
Resumo: | In this report we have analysed the peripheral blood lymphocyte of several patients with chronic hepatitis B virus infection with flow cytometry. Based on the presence and absence of the HBeAb, patients were divided into two groups. In both, all the patients were HBsAg positive with normal range of serum alanine aminotranferase (23.9 ± 17.8). We have found that the immunophenotypic profiles of patients were different from healthy donors with significant decrease in CD3+ T cells, specially CD8+ T cells and a siginificant increase in the CD19+ B cells. The differences were seen in other subset of T cells (CD4+) or NK cells (CD56+/CD16+ ) and HLA-DR markers were not significant. When the phenotypic profiles of both groups were compared with each other, such changes were more dominant in group II, with HBeAb positive than in group I, with HBeAb negative. Also, we have seen a correlation between the increase of CD19+ B cells and the decrease of CD3+ T cells. No such correlation was observed with other cells.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600009
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702001000600009
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.5 n.6 2001
Fonte: | info:eu-repo/semantics/openAccess