Data/hora: 06/06/2024 00:20:54

Provedor de dados: | 55
País: | Brazil
Título: | Challenges in the development of drugs for the treatment of tuberculosis
Autores: | Shehzad,Adeeb; Rehman,Gauhar; Ul-Islam,Mazhar; Khattak,Waleed Ahmad; Lee,Young Sup.
Data: | 2013-02-01
Ano: | 2013
Palavras-chave: | Antibiotics; Drug resistance; Tuberculosis; Pathogen.
Resumo: | Tuberculosis infection is a serious human health threat and the early 21st century has seen a remarkable increase in global tuberculosis activity. The pathogen responsible for tuberculosis is Mycobacterium tuberculosis, which adopts diverse strategies in order to survive in a variety of host lesions. These survival mechanisms make the pathogen resistant to currently available drugs, a major contributing factor in the failure to control the spread of tuberculosis. Multiple drugs are available for clinical use and several potential compounds are being screened, synthesized, or evaluated in preclinical or clinical studies. Lasting and effective achievements in the development of anti-tuberculosis drugs will depend largely on the proper understanding of the complex interactions between the pathogen and its human host. Ample evidence exists to explain the characteristics of tuberculosis. In this study, we highlighted the challenges for the development of novel drugs with potent bacteriostatic or bactericidal activity, which reduce the minimum time required to cure tuberculosis infection.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100012
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2012.10.009
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.17 n.1 2013
Fonte: | info:eu-repo/semantics/openAccess