Data/hora: 01/06/2024 06:29:21

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Hepatitis C treatment: shorter and better?	
Autores: 	Araújo,Evaldo Stanislau Affonso de; Courtouké,Cláudia; Barone,Antonio Alci.	
Data: 	2007-02-01	
Ano: 	2007	
Palavras-chave: 	HCV; Interferon; Viral kinetics.	
Resumo: 	Herein, we present a synthesis of two publications that evaluate an abbreviated therapeutic approach to treating chronic hepatitis C virus (HCV) infection. Based on those publications, we discuss the use of the early virologic response (EVR) as a tool for the optimized management of patients under treatment, as well as reviewing concepts of HCV viral kinetics. The fourth-week EVR, characterized by HCV RNA dropping to undetectable levels, allows individuals infected with HCV genotype 1 and presenting low baseline viral loads to be treated with the combination of pegylated interferon and ribavirin for 24 weeks, whereas individuals infected with HCV genotypes 2 or 3 can be treated for only 12 weeks. Therefore, by adopting abbreviated treatment regimens optimized through early prediction of sustained viral response, it is possible to increase the number of patients treated without incurring the excess costs related to high rates of treatment failure and management of adverse outcomes, as well as avoiding the risks of unnecessarily exposing patients to drugs that have the potential to be highly toxic.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100026	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702007000100026	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.11 n.1 2007	
Fonte: 	info:eu-repo/semantics/openAccess