Data/hora: 14/06/2024 16:29:34

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Clinical presentation and follow up of children with congenital toxoplasmosis in Brazil	
Autores: 	Sáfadi,Marco A. P.; Berezin,Eitan N.; Farhat,Calil K.; Carvalho,Eduardo S.	
Data: 	2003-10-01	
Ano: 	2003	
Palavras-chave: 	Congenital toxoplasmosis; Chorioretinitis; Neurologic manifestation.	
Resumo: 	We evaluated the clinical presentation and determined the ocular and neurologic sequelae in children with congenital toxoplasmosis in Brazil, taking into consideration the shortage of national publications on this disease. Follow-up evaluations were made of 43 children with congenital toxoplasmosis referred to Santa Casa de São Paulo, during a period of at least five years. Selection of the cases was based in clinical and laboratory criteria. A clear predominance of children with subclinical presentation of the disease at birth (88%) was found. Of the 43 children, 22 (51%) developed neurological manifestations. Using skull radiography, we detected neuroradiologic alterations in seven children (16%) and with tomography in 33 children (77%). Neurological sequelae were identified in 15 children (54%) in the group with cerebral calcifications and in 7 (47%) in the group without cerebral calcifications. We observed chorioretinitis in 95% of the cases. Reactivation of cicatricial lesions and the emergence of new ocular lesions were observed in five cases. The most frequent neurological manifestation was a delay in neuropsychomotor development. Most remarkable was the finding that cerebral calcifications were not associated with a higher incidence of neurological sequelae among the children. Chorioretinitis was the main ocular sequel of the infection, found in nearly all children; it can manifest years from birth, even in children submitted to specific therapy during the first year of life, highlighting the importance of a follow-up of these children.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500007	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702003000500007	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.7 n.5 2003	
Fonte: 	info:eu-repo/semantics/openAccess