Data/hora: 05/06/2024 09:12:59

Provedor de dados: | 55
País: | Brazil
Título: | Microbiological epidemiological history of meningococcal disease in Rio de Janeiro, Brazil
Autores: | Barroso,David Eduardo; Carvalho,DM; Casagrande,ST; Rebelo,MC; Soares,V; Zahner,V; Solari,CA; Nogueira,SA.
Data: | 2010-06-01
Ano: | 2010
Palavras-chave: | Neisseria meningitidis; Meningococcal disease; Epidemic; Meningitis; Sepsis.
Resumo: | The main objectives of the present study were to investigate the clinical and laboratory features of meningococcal disease in the city of Rio de Janeiro, Brazil, during the overlap of 2 epidemics in the 1990s. We conducted a study of a series of cases of meningococcal disease admitted in a Meningitis Reference Hospital. All clinical isolates available were analyzed by means of microbiological epidemiological markers. In 1990, Neisseria meningitidis serogroup B:4,7:P1.19,15, 1.7,1 sulfadiazine-resistant of the ET-5 complex emerged causing epidemic disease. Despite mass vaccination campaign (VaMengoc B+C®), the ET-5 clone remained hyperendemic after the epidemic peaked. In 1993 to 1995, an epidemic of serogroup C belonged to the cluster A4 overlapped, with a significant shift in the age distribution toward older age groups and an increase of sepsis. Serogroup C epidemics are a recurrent problem in Rio de Janeiro, which can be hindered with the introduction of a conjugate vaccine. We hope the data presented here brings useful information to discuss vaccines strategies and early management of suspected cases.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300008
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702010000300008
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.14 n.3 2010
Fonte: | info:eu-repo/semantics/openAccess