Data/hora: 11/06/2024 02:33:02

Provedor de dados: | 55
País: | Brazil
Título: | Posaconazole as rescue therapy in African histoplasmosis
Autores: | Gonçalves,Daniel; Ferraz,Catarina; Vaz,Luisa.
Data: | 2013-02-01
Ano: | 2013
Palavras-chave: | Posaconazole; Histoplasmosis; Salvage therapy.
Resumo: | Posaconazole Histoplasmosis Salvage therapy African histoplasmosis is a granulomatous mycosis caused by Histoplasma capsulatum var. duboisii. Treatment is usually extrapolated from guidelines for classical histoplasmosis, and includes 2-4 weeks of amphotericin B followed by a step-down maintenance therapy with itraconazole. Pediatric usage of posaconazole, an oral second-generation azole, remains off-label, but recent surveys show that it is safe and well tolerated in children. We report a case of disseminated African histoplasmosis in a 12-year-old boy from Guinea-Bissau. Therapy with amphotericin B and itraconazole led to a progressive clinical deterioration. A dramatic and lasting improvement was observed using posaconazole. He completed 12 months of therapy. No relapse was noted during or 3 months after treatment. We report that posaconazole may be a safe and efficacious drug in the salvage management of disseminated AH, either in patients with disease refractory to conventional anti-fungal therapy, or in patients whose serious adverse effects of first-line drugs preclude its use.
Tipo: | Info:eu-repo/semantics/report
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100018
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1016/j.bjid.2012.06.027
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.17 n.1 2013
Fonte: | info:eu-repo/semantics/openAccess